Despite its well-known sedative properties, chloroform is rarely used for drug-facilitated sexual assault DFSA as its administration cannot be achieved without the victim's knowledge: we report an unusual case of DFSA using this solvent. A year-old woman declared that her partner get her to sleep using chloroform the previous night. When she waked up at 3 am, her hands were tied. She immediately suspected violence and sexual penetration. Toxicological blood screening using a liquid chromatography—electrospray coupled tandem mass spectrometry method highlighted the presence of bamifylline and theophylline, two therapeutics of asthma. These results were consistent with an exposure to chloroform by inhalation and demonstrate that there is no limit in the use of chemical weapons in DFSA.
Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice
Chloroform abuse: 1. : European Journal of Anaesthesiology | EJA
Colleague's E-mail is Invalid. Your message has been successfully sent to your colleague. Save my selection. When James Y. Simpson  described the ease with which chloroform could be used to produce unconsciousness without specialized equipment these advantages were not lost on the criminal fraternity who were not slow to adopt the drug in pursuit of their nefarious practices. Unlike the use of the cudgel, the garrotte and the pistol, according to English law it was not a felony to administer chloroform to another unless the purpose of the act was murder! As early as , it was widely known to the public that chloroform could be used to perpetrate various forms of crime such as rape and robbery as witnessed by a well-known cartoon in Punch magazine of that year.
In mice, only males are susceptible to chloroform CHCl3 nephrotoxicity and the susceptibility appears to be related to renal mixed function oxidase activity. There were sex-related differences of renal cytochrome P and b5 concentrations and of ethoxycoumarin O-deethylase activity in mouse kidneys; in all cases activity was higher in males. Castration of male mice eliminated susceptibility to CHCl3 nephrotoxicity and reduced renal mixed function oxidases to concentrations observed in female mice. Treatment of male and female mice with testosterone increased the susceptibility to CHCl3 nephrotoxicity and increased renal mixed function oxidases to similar activities in both sexes. Previous data have suggested that CHCl3 is metabolized in situ by the kidney, possibly by a mechanism similar to that occurring in the liver.